The Effect of Aconitine on the Giant Axon of the Squid

Demonstration of Two Stable Potential States in the Squid Giant Axon under Tetraethylammonium Chloride

1. Intracellular injection of tetraethylammonium chloride (TEA) into a giant axon of the squid prolongs the duration of the action potential without changing the resting potential (Fig. 3). The prolongation is sometimes 100-fold or more. 2. The action potential of a giant axon treated with TEA has an initial peak followed by a plateau (Fig. 3). The membrane resistance during the plateau is prac...

The effect of sodium ions on the electrical activity of giant axon of the squid.

Simulation of the Wave of Action Potential Propagation over the Length of the Axon at Various Times by Comsol Multiphysics Software

In this study, simulation of Fitzhugh nagumo model in order to generation and propagation of the wave of action potential over the length the of the squid giant axon and survey the passage of time effect in wave propagation have been explored. Simulation has been performed by using the Comsol Multiphysics 3.5 a software. So that, in this simulation, squid giant axon is intended to form hollow c...

Action potentials occur spontaneously in squid giant axons with moderately alkaline intracellular pH.

This report demonstrates a novel finding from the classic giant axon preparation of the squid. Namely, the axon can be made to fire autonomously (spontaneously occurring action potentials) when the intracellular pH (pH(i)) was increased to about 7.7, or higher. (Physiological pH(i) is 7.3.) The frequency of firing was 33 Hz (T = 5 degrees ). No changes in frequency or in the voltage waveform it...

Current-Voltage Relations in the Lobster Giant Axon Membrane Under Voltage Clamp Conditions

The sucrose-gap method introduced by Stämpfli provides a means for the application of a voltage clamp to the lobster giant axon, which responds to a variety of different experimental procedures in ways quite similar to those reported for the squid axon and frog node. This is particularly true for the behavior of the peak initial current. However, the steady state current shows some differences....